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However, in acute intensive care unit (ICU) settings, where patients require mechanical respiratory support, a multitude of factors including infection, accumulation of inflammatory cells, airway dehydration, reduced cough reflexes, supra-normal oxygenation, and mechanical stress from ventilation can lead to changes in mucus characteristics and increased mechanical impedance to mucociliary clearance

doi: 10.1016/j.schres.2014.07.053 116 KopczynskaMZelekWTouchardSGaughranFDi FortiMMondelliVet al

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