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5hmC may either be an intermediate in the removal of 5mC by an active demethylation process (Guo et al., 2011) or it may be an epigenetic modification in its own right, regulating chromatin or transcriptional factors (Szulwach et al., 2011)

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doi: 10.3389/fchem.2020.583272 Received 14 July 2020 Accepted 13 October 2020 Published 12 November 2020 Volume 8 - 2020 Edited by Chun Xu, The University of Queensland, Australia Reviewed by Junfeng Zhao, Jiangxi Normal University, China

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