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However, things like smoking, alcohol use, and stress can cause an excess of free radicals

doi: 10.1089/ars.2009.2697

The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions