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Several non-clinical and clinical research studies have investigated the influence of non-enzymatic, enzymatic, and natural antioxidants on preventing various diseases [21]

The most robust clinical evidence to date concerns the improvement of muscular and metabolic parameters (strength, endurance, insulin sensitivity) and the modulation of chronic inflammation. A 2024 randomised trial comparing NAD IV with NR IV in healthy adults showed that both modalities increase the available NAD pool, with a favourable safety profile

erinaceus sporophores is still controversial, even though oral sporophore supplementation exerted a nootropic action in pilot clinical trials, as reported in the Section 8 [72,73,74]

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