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If you need to take pain-relieving medications long-term, discuss other treatment options to ease muscle spasms with your healthcare provider, such as: Topical pain relievers (creams and ointments) are less likely to cause systemic side effects compared to oral medications for pain relief Low-impact physical activities such as stretching, yoga, and tai chi Relaxation techniques Consult a healthcare provider before taking alternatives such as acetaminophen or other muscle relaxants, especially those with the following: A history of allergic reactions to ibuprofen or cyclobenzaprine

Injectable Vitamin B12 may be given subcutaneously or intramuscularly

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The two co-primary endpoints were analyzed independently of each other, and for the trial to be considered to be positive (indicating a significant benefit of semaglutide versus placebo), statistical superiority for both co-primary endpoints was required to be demonstrated