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In animal models of redox homeostasis on fatty liver diseases, physical exercise interventions primarily are aerobic exercises, such as treadmill running and swimming

An imbalance in pro- and antioxidants, known as oxidative stress, stimulates inflammatory responses that can lead to the development and maintenance of allergic disorders (95, 96)

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Including the long term extension study, the adverse reactions reported as the primary reason for discontinuation by 1% of 248 valproate-treated patients were alopecia (6%), nausea and/or vomiting (5%), weight gain (2%), tremor (2%), somnolence (1%), elevated SGOT and/or SGPT (1%), and depression (1%)