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In breast cancer cell lines (MCF-7), activation of IGF/PI3K signaling enhances mitochondrial homeostasis by increasing the number of new mitochondria and levels of oxidative phosphorylation and promotes the degradation of damaged mitochondria (mitochondrial autophagy) by increasing BNIP3, a protective mechanism that ultimately influences the cancer treatment response and evolution of the cancer phenotype (53)

Riboflavin Riboflavin is a component of flavocoenzymes involved in energy metabolism, antioxidant functions, and iron metabolism

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Mg_F expresses VEGFA , which may promote angiogenesis and support OPC survival and differentiation, raising the possibility that this state is associated with repair 40,41