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doi: 10.3389/fphar.2023.1196287 Received 29 March 2023 Accepted 02 May 2023 Published 15 May 2023 Volume 14 - 2023 Edited by Daniela Gabbia, University of Padova, Italy Reviewed by Xiao Li, Shandong Provincial Qianfoshan Hospital, China Hartmut Kuhn, Charit University Medicine Berlin, Germany Updates Copyright 2023 Lu, Hu, Chen, Li, Yuan, Tian, Cao and Qiu

Ethics declarations Ethics approval and consent to participate The care and use of experimental animals in this study were approved by the Animal Care and Use Committee of Kagoshima University (approval numbers VM15055 and VM15056 for the rabbits and mice, respectively)

Additional clinical evidence of cyanide's neurological effects in humans comes from the ingestion of inadequately detoxified cyanogenic cassavaa staple food for ~600 million people, which leads to a neurological syndrome called Konzo [16, 17, 18, 43, 44, 45]

Kinetics of the Yeast Cystathionine -Synthase Forward and Reverse Reactions: Continuous Assays and the Equilibrium Constant for the Reaction