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Evidence Level Strong preclinical What to Expect Week 1 What you might notice Possible mild GI adjustment as body adapts Subtle increase in energy levels Perhaps feeling slightly warmer than usual Many users notice nothing dramatic yet What's normal Mild stomach adjustment that improves daily Slightly elevated energy, especially in mornings No dramatic changesthe compound works gradually What's next Continue at starting dose if tolerating well Stay hydrated and maintain regular eating Track energy levels and any changes in a simple log Weeks 2-4 What you might notice More consistent energy throughout the day Possibly improved exercise tolerance or endurance Early changes in body composition may begin Better recovery from physical activity What's normal Side effects typically resolve by now Energy levels stabilize at new baseline Exercise feels slightly easier What's next Consider increasing to standard dose if needed Add or maintain regular exercise for synergistic effects Continue monitoring body composition and energy Weeks 5-8 What you might notice More noticeable improvements in endurance Visible changes in body composition (reduced fat) Improved metabolic markers if tested Enhanced exercise performance and recovery What's normal Consistent energy and endurance improvements Gradual fat loss, especially with exercise Feeling metabolically 'optimized' What's next Maintain protocol through completion Consider bloodwork to track metabolic markers Plan for post-cycle transition Weeks 9-12+ What you might notice Peak effects typically reached Significant improvements in body composition Notable enhancement in exercise capacity Metabolic benefits may persist after stopping What's normal Plateauing of effects at higher doses Maintained improvements with consistent use Ready to cycle off or continue as protocol dictates What's next Complete your planned cycle Some users take a break before another cycle Maintain results through continued exercise and diet Signs It's Working Metabolic Improvements Increased energy and reduced fatigue during daily activities Better exercise endurancerunning farther, lasting longer Gradual reduction in body fat, especially abdominal area More stable blood sugar levels (if monitored) Improved recovery after physical exertion Physical Performance Workouts feel easier at the same intensity Able to exercise longer before feeling exhausted Faster return to baseline after intense activity Improved cardiovascular endurance Better metabolic flexibility during exercise Measurable Markers (if tested) Improved fasting glucose or HbA1c levels Better lipid profile (cholesterol, triglycerides) Reduced inflammatory markers Improved insulin sensitivity on testing Changes in body composition measurements Not Seeing Results

26 Aim We reviewed current practices in OWS management and presented therapeutic interventions that have been studied and published between January 2010 and November 2023, focusing on research that may inform OWS management while increasing IMF exposure