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Changes in elasticity, hydration, resilience, recovery capacity, and structural organization may precede visible reductions in wrinkles or laxity

Based on preclinical literature reviews, Pickart and colleagues proposed broader genomic effects, suggesting that, in sequencing models, GHK-Cu may influence approximately 31% of genes altered during skin aging, shifting expression patterns toward a younger phenotype [1]

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Stability issues, particularly during long-term storage, and the limited availability of surfactants and cosurfactants further constrain their application [191]