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This lightens pigmentation

These effects are frequently characterized in controlled laboratory settings

Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia

Consequently, changes in definite cytochrome P450 enzymes, as those previously evidenced in livers of patients with steatosis, but also in vivo models of steatosis (in experimental animals) and in vitro models of fat-overloaded cells, pose major impact on drug-induced hepatotoxicity (Gmez-Lechn et al., 2009), on the basis that CYP 3A4 is the main responsible for the metabolism of fentanyl (Figure 2) (Tateishi et al., 1996)