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Ther Adv Infectious Dis

In vivo, M1 macrophage exosomes with low miR-663b expression attenuated pulmonary vascular remodeling in PH rats, suggesting that exosomal miR-663b exacerbates PASMC dysfunction and PH progression by suppressing the AMPK/SIRT1 axis and promoting inflammation

Conversely, downregulation of ChaC2 decelerates the cell cycle progression of hESCs and triggers cell death (78), underscoring its pivotal role in regulating human growth and development

Cobalamin (vitamin B 12 ) is particularly noteworthy, since the incidence of B 12 deficiency correlates with COVID-19 disease (Wee 2021), but B 12 supplements increase the risk of disease severity (Dalbeni et al