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In addition, IRE1 kinase can up-regulated the expression of apoptosis signal regulated kinase 1(ASK1) and then activate c-Jun N-terminal kinase (JNK) to promote apoptosis through the inhibition of BCL-2 protein family (64, 65)

However, despite the considerable amount of research in this area, the underlying molecular mechanisms by which alcohol abuse causes cellular toxicity and organ damage remain to be further characterized