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Hypoxia also induces cellular adaptations which can hinder the efficacy of chemotherapy, such as reduced cellular uptake of drugs due to increased cellular acidity and drug efflux pump expression [82], whilst some chemotherapeutic agents require oxygen in order to facilitate their cytotoxicity [24]

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

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If you have a weak immune system