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There is a lack of long-term data beyond 23 months, and large-scale, randomized controlled trials are limited, according to Anetta Reszko, MD, a board-certified dermatologist and dermatologic surgeon, a clinical assistant professor of dermatology at Weill Cornell Medical College

This does not guarantee absolute safety, but it does suggest a favorable risk profile for most healthy adults

100% of 12 mg participants achieved 5% weight loss

A 2008 study published in the Bulletin of Experimental Biology and Medicine reported significant anxiolytic effects with preserved cognitive performance, a profile not typically seen with conventional anti-anxiety compounds