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Metabolic phenotype-based clustering To investigate whether metabolic phenotypes of certain cell populations could be used as predictive indicators of disease severity, dimensionality reduction at both a single-cell and sample-wide resolution was done only on key identified differentially expressed metabolic genes to see if cells/samples would cluster according to disease severity

Open communication with your healthcare provider is essential to tailor treatment safely

The first and rate-limiting step of glutathione synthesis, the formation of -glutamylcysteine from glutamate and cysteine, is normally subject to negative feedback inhibition by glutathione itself [41]

24,25 Similarly, apoptosis-inducing factor in the nucleus causes chromatin condensation and DNA fragmentation