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Furthermore, open-label trials utilizing high-dose hydroxycobalamin have shown marked clinical improvements in ME/CFS patients, specifically correlating with the vitamin's ability to act as a nitric oxide scavenger

The observed differences appear to be dependent on the animal model, as previous studies have shown that MitoQ is well tolerated at concentrations up to 500 M in drinking water over several weeks, without causing adverse effects on behavior or metabolism (57, 83)

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