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10.1038/ajg.2014.330 28

Fourteen of the 16 patients (87.5%) reported significant pain relief

However, molecular analysis reveals that 126 DNA methylation sites remain altered (112), while 23 genes exhibit sustained expression changes (113), suggesting residual heritable effects that may contribute to long-term reproductive vulnerabilities

[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head