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Glutathione depletion is accompanied by increased neuronal nitric oxide synthase activity

Some things that increase the demand for glutathione and therefore deplete glutathione levels include: 5 Alcohol consumption: Your body uses glutathione to metabolize alcohol so the more alcohol you consume the more glutathione your body uses up

This work was supported by the National Natural Science Foundation of China (82370069, 82305214), the Natural Science Foundation of Hunan Province (2025JJ60771, 2023JJ40401), the open Fund for the Cultivation Base of the State Key Laboratory of Traditional Chinese Medicine Powder and Innovative Medicine Research in Hunan Province (2024PTKF1007), the Key Research and Development Program of Ningxia Autonomous Region (2023BEG02033) and the undergraduate Research and Innovation Fund of Hunan University of Traditional Chinese Medicine (2025BKS146)

doi:10.1016/s0946-672x(00)80035-8