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These findings suggest a potential mechanism for the beneficial effects of CB 1 receptor antagonism at the behavioral level

I bring this up because I've read that B12 is known to raise histamine levels, injections in particular

Given that the regulation of the intracellular cytoskeleton is dependent on the presence of ATP to stimulate the contraction of actin-myosin complexes, a reduction in ATP concentration caused by NSAIDs was found to impair TJs and reduce cellular polarity (Knig et al