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Among the 101 participants receiving the highest 4.5 mg/week dose, the most frequently reported side effects included: Indigestion: 4% Headache: 7% Loose stools: 7% Vomiting: 8% Allergic reactions: 10% Fatigue: 20% Constipation: 21% Injection site reactions: 43% Nausea: 47% Serious side effects in this phase 2 trial occurred in 2% to 7% of the cagrilintide groups, compared to 4% in the liraglutide group and 3% in the placebo group

Very strong correlation was established between GCLc and GR (0.974, p =0.005) and GS (0.935, p =0.020) expression and between GS and GR (0.886, p =0.045) expression levels (Table