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Exome sequencing of ALS and rare-variant analyses identified loss-of-function mutations in TBK1 (encoding TANK-binding kinase 1) in 13 of 252 familial ALS pedigrees, but not in sporadic ALS (Freischmidt et al., 2015)

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According to The European Food Safety Authority (EFSA, 2015), no adverse effects have been associated with excess B12 intake from food or supplements in healthy individuals