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In addition, the study of a Mat1a KO-derived HCC cell line (SAMe-D) demonstrated that LKB1 regulates Akt (protein kinase B)-mediated survival through its hyperphosphorylation and also blocks the apoptotic response through phosphorylation and retention of p53 in the cytoplasm [112]

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Mier-Cabrera et al (129) demonstrated that combined supplementation of vitamins E and C reduced oxidative stress markers, such as MDA and LOOH, in the plasma and peritoneal fluid of patients with endometriosis, although no improvement in pregnancy rates was observed