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Under conditions of hypoxia, nutrient deprivation, or impaired mitochondrial function, cancer cells modulate NADPH and GSH levels through key metabolic pathways such as the pentose phosphate pathway (PPP), FAO, and glutamine metabolism, thereby establishing a metabolicredox feedback loop [39,40,41]

Since the influx of glutamine across BBB is relatively modest, the majority of CNS glutamine is synthesized endogenously by astrocytes specifically (the amidation of glutamate to glutamine by glutamine synthetase) [37]

Table 3 Nutrient composition and content in C

They form when the wound-healing response produces too much collagen