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The novelty of this review lies in its integrative approach, moving beyond a mere description of disparate pathways to synthesize a coherent framework that connects key metabolic nodessuch as the mammalian target of rapamycin (mTOR)-hypoxia-inducible factor 1-alpha (HIF-1)-glycolysis axis, AMP-activated protein kinase (AMPK)-FAO signalinginto a dynamic immunometabolic network ( Figure 1 )

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These guidelines encompass the use of an aqueous extract kava (only the root or rhizome) in participants without previous liver disease or history, ethanol abuse and exclude participants medicated with antipsychotics, anxiolytics or antithrombotic drugs [59]