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Studies have shown that X-ray irradiation reduces KGN cells viability, alters mitochondrial morphology, induces intracellular iron accumulation, and triggers lipid peroxidation, ultimately leading to ferroptosis (Zhao et al., 2023)

In contrast, targeting the adeno-associated virus integration site 1 locus ( AAVS1 ) did not affect the levels of IRFP670-positive cells and hence served as negative control