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Extracellular signaling Even though mostly executing their functions intracellularly, there is a substantial portion of extracellular HSP70s released in endolysosomes, together with such proteins as cathepsin D and LAMP1 with the help of ATP-binding cassette transporters (Mambula et al., 2007), exosomes (Takeuchi et al., 2015) and microvesicles (Komarova et al., 2021)

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Chen P, Cai H, Bai W et al (2023) Global prevalence of mild cognitive impairment among older adults living in nursing homes: a meta-analysis and systematic review of epidemiological surveys