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The names of the repository/repositories and accession number(s) can be found below: Abbreviations FAERS: FDA adverse event reporting system ICSR: Individual case safety report irAEs: Immune-related adverse events AEs: Adverse events PFS: Progression-free survival OS: Overall survival ROR: Reporting odds ratio PRR: Proportional reporting ratio BCPNN: Bayesian confidence propagation neural network MGPS: Multi-Item gamma poisson shrinker WSP: Weibull shape parameter ICIs: Immune checkpoint inhibitors MedDRA: Medical dictionary for regulatory activities SOC: System organ class HLGT: High-level group term HLT: High-level term PT: Preferred term LLT: Lowest level term DEMO: Patient demographic and administrative information DRUG: Drug information REAC: Adverse event coding OUTC: Patient outcomes RPSR: Report sources THER: Therapy start and end dates INDI: Indications for drug administration IC: Information component SIADH: Syndrome of inappropriate antidiuretic hormone secretion DI: Diabetes insipidus IQR: Interquartile range References Stoff, R

thermoleorovorans reference genome and transcripts-per-million (TPM) values were calculated using the RNA-seq analysis tool of CLC Genomics Workbench (read alignment parameters: mismatch cost, 2

Of note, ATFs exhibit complex context-dependent versatility in macrophage-mediated immune responses

Dimethoxy curcumin (DMC) could decrease mitochondrial dysfunction in mutated TDP-43 stably transfected cell lines (Lu et al., 2012) (Table 1)