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This increases oxidative stress, and leaves the body vulnerable to further damage from toxins

In this sense, this review aims to provide an overview of the AR signaling in PC, its interaction with miRNAs and curcumin, and the currently available curcumin nanoformulations that can be implemented as possible therapeutic solutions in both normal and aggressive forms of PC

Under physiological conditions, about three-quarters comes from senescent erythrocytes undergoing catabolism in the reticuloendothelial system, which contains splenic macrophages and hepatic Kupffer cells, and the remaining one-quarter of hemoglobin comes from ineffective red blood cell production and enzymes containing hemoglobin (4)