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This tumor EV-mediated metabolic reprogramming negatively impacts cancer patients by driving energetic dysfunctions, such as cancer cachexia, that culminate in reduced quality of life, treatment response, and overall survival [28]

For sudden cardiac death (SCD), the relationship with alcohol consumption appears to be J shaped, meaning that light-to-moderate alcohol consumption is associated with a reduced risk while no alcohol or high alcohol consumption are associated with an increased risk of SCD

Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW, Eddleman KM, Jarrett NM, LaBresh K, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF