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Li P, Xia C, Kong X, Zhang J (2024) Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications

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As a critical molecule in cellular energy metabolism and DNA repair, insufficient NAD+ directly triggers a series of metabolic abnormalities, including impaired mitochondrial function, reduced energy metabolism efficiency, and weakened DNA repair capacity