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334 This process leads to the induction of T-cell anergy, cell death, the differentiation of CD4+ cells into Tregs and polarization of macrophages to acquire an immunosuppressive phenotype

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(3) Instituto de Nutrio Josu de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil Diabetology & Metabolic Syndrome 2026: PO148 Introduction: Among the rare forms of diabetes, Maturity-Onset Diabetes of the Young (MODY) is notable, characterized by onset before age 25, autosomal dominant inheritance, and a primary defect in pancreatic cells