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The Journal of clinical investigation 115 , 11111119, doi: 10.1172/JCI25102 (2005)

Two Phase I, Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies of TAS-109, a novel nucleoside analogue with 14 days and 7 days continuous infusion (CI) schedules, 2008

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Following UV radiation, many inflammatory mediators (such as inflammation-associated cytokines, chemokines, prostanoid-synthesizing enzyme COX-2 and lipid mediators) are released from cells residing in the skin, which is likely to be mediated by the UV-induced release of self-RNAs as a damage-associated molecular pattern dependent on Toll-like receptor 3 (TLR3) and Toll-like receptor adaptor molecule 1 (TRIF) from keratinocytes [104, 125, 126]