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Moderate deficiency may include obvious macrocytic anemia, glossitis, as well as some mild or subtle neurological features, such as distal sensory impairment.[] Severe deficiency is characterized by bone marrow suppression, neurological features, and the risk of cardiomyopathy

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FIGURE 7 Theoretical modeling combined with empirical evidence has long indicated that a mixture of both phenotypic plasticity and bet hedging per se is most likely to optimize fitness in large populations experiencing short-term environmental changes (Cohen, 1966