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Indeed, recent work has likewise implicated cell cycle arrest, induced either by p53 activation or CDK4/6 inhibition, in sensitizing fibrosarcoma cells to GPX4 inhibition 51

Rational design of a polymer with robust efficacy for intracellular protein and peptide delivery

HRAR had similar utility: accuracy (0.61), Sens 37%, Sp 67%, PPV 22%, and NPV 81%

Persistent ferroptosis in alveolar and endothelial cells triggers pro-fibrotic signaling pathways, such as those involving TGF- and connective tissue growth factor (CTGF), which drive ECM deposition and fibroproliferation