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AGEs-induced intestinal barrier dysfunction and inflammation were also evident, as marked by the increased gut permeability, reduced expression of TJ-proteins, localized synthesis of pro- inflammatory cytokines, and activation of the innate signaling pathways (e.g., RAGE)

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Ageing Approximately 30 years ago, the initial long-lived species was isolated from C

Under these conditions, NO triggers a programmed cell death with markers of both apoptosis and necrosis characterized by an early step of free radicals production followed by a late requirement for signaling on the sGC/cGMP/PKG pathway (Canals et al., 2001)

Additionally, we examine the scientific process, the practical and ethical challenges of pursuing groundbreaking discoveries, and the emotional toll of striving for recognition in ones profession