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This causes the cell nucleus to read the inserted gene and instructs its natural mRNA to begin making the protein instructed by the inserted gene

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Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A 2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter

First, the identified candidate genes and pathways were derived from transcriptomic and integrative bioinformatics analyses, and causal relationships with chemoresistance were not experimentally validated