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Int Immunopharmacol 19(1):174177

Silencing SIRT1 gene or inhibiting it pharmacologically with Ex-527 can reduce cell ferroptosis and inhibit EMT, 90 suggesting that epigenetic reprogramming of EMT helps to promote ferroptosis in HNC cells

However, this relationship has not been observed in animal-derived peptides ( Bacillus mojavensis A21 protease fraction (HFFD + GPH-A) and triggerfish protease fraction (HFFD + GPH-TF), respectively, could reduce blood glucose level and hepatic glycogen and protect the kidney of high-fat-high-fructose diet (HFFD)-fed rats by reversing the HFFD-induced uric acid reduction and creatinine level increase in serum and preventing some HFFD-induced changes in the kidney (including tubular dilatation, glomerular space, vacuolization, and epithelial cells necrosis of the proximal tubule) (Figure 10C)

10.1021/jasms.2c00379 28 CalabresiP.Di LazzaroG.MarinoG.CampanelliF.GhiglieriV