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The diagnosis of MS is made according to clinical, radiological and, recently, biochemical criteria 3 and after diagnosis, early prediction of MS outcomes is a challenge because, until now, there is no strong candidate biomarker able to detect, early during disease course, those people with MS (pwMS) with subclinical neuronal damage and, therefore, more prone to develop clinical progression and functional impairment over time 4

( h-i ) Quantification of total tumour number ( h ) and tumour area ( i ) in colons from CD-, HFD-, and KD-fed mice

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In addition, NAC, a precursor of reduced glutathione (GSH), suppressed CSE-induced cell death (Supplementary Fig