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Finally we show that the intrinsic substrate specificity of Tyr kinases has remained fundamentally unchanged from worms to humans, suggesting that the fidelity between Tyr kinases and their protein substrate sequences has been maintained across hundreds of millions of years of evolution

Secondary analysis using an ELISA based approach confirms GPx3 is substantially reduced in children affected with konzo To validate the findings obtained using proteomic-based applications, we sought to determine if the reduced abundance of GPx3 protein in konzo affected children as compared to their unaffected siblings could also be detected using an orthogonal ELISA-based approach

This aligns with findings showing that mechano-transduction pathways regulate epithelial integrity and inflammatory cascades in COPD pathogenesis

L., Daniel, C