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Therapeutic targeting of AURKA using either the specific inhibitor Alisertib or genetic knockdown approaches significantly attenuates the proliferative and migratory capacities of HNSCC cells (Jia et al., 2024)

Bioavailability describes the rate and extent of compound uptake into systemic circulation ( , pharmacokinetics were determined in several human studies describing urinary metabolites ( 1.2.2 Pharmacodynamics Single pharmacodynamic aspects, allowing detailed determination of specific cellular responses, can be studied in detail in cell cultures

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Funding The study was supported bythe National Institutes of Health R01DK117481 (D.C.), R01AG063404 (D.C.), R01AG063389 (D.C.), R01AG082105 (D.C.), National Institute of Food and Agriculture (D.C.), Dr