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If you take antacids , PPIs, or other acid blockers, you likely need B12 in a non-oral form

Two possible sites were identified in the catalytic subunit of glutamate-cysteine ligase (GCLC), the rate limiting enzyme for GSH synthesis

Identification of a Ctr1-independent copper transport system

Dehydration makes nausea significantly worse For diarrhea: Increase fiber intake gradually, not suddenly Stay hydrated with electrolyte solutions, not just plain water Avoid sugar alcohols and artificial sweeteners, which can worsen GI symptoms For constipation: Increase water intake to at least 2-3 liters daily Add magnesium citrate if needed (a gentle, effective option) Include high-fiber vegetables and fruits in your diet When to slow the escalation If you experience side effects that significantly impact your daily function, extend the current dose phase by 2-4 additional weeks before escalating