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Data availability All data generated during this study are included in this published article and its supplementary information files, and the raw data of iTRAQ quantitative proteomics generated in this study have been deposited to the ProteomeXchange Consortium ( via the iProX partner repository [44, 45] with the dataset identifier PXD041754

29 For patients with moderate hyperkalemia, the reduction was 0.87, 0.97, and 0.92 mEq/L for patients starting at 8.4 g twice daily, 12.6 g twice daily, and 16.8 g twice daily, respectively