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269 Another study suggested that PS1 mutations may lead to the opening of another calcium ion channel, two pore segment channel 2 (TPCN2), whose markedly enhanced activity greatly promotes lysosomal calcium efflux and lysosomal alkalinization

Evidence for enhanced vascular superoxide anion production in nitrate tolerance

After isolating the left femoral artery from the surrounding tissues, we induced ischemia by using a microvascular clamp to occlude the artery for 2 h