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At present, the treatment of PD only ameliorates and alleviates the partial symptoms and signs at the early and mid-stages, cannot prevent and squelch the pathological lesions of PD, and cannot reverse and stop the progression of PD (2)

All participants were administered an identical intervention (1cm 3 of saline containing 200 mg GSH) using a syringe attached to a Mucosal Atomization Device supplied by Wolfe-Tory Medical (Salt Lake City, UT, USA)

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Hydroxyl radical can diffuse only about the diameter of a typical protein, which is limited to much less than that of peroxynitrite [81,91]