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BAL fluid and intracellular GSH pathways correlate with HAEC T2-associated gene expression To determine whether these in vitro findings were reflected ex vivo, BAL fluid GSSG levels were compared to fresh HAEC expression of T2-related genes from 2 different RNA-Seq databases (SARP3 and IMSA), which were harmonized and merged as outlined in the Methods (Table 3)

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Together, these data demonstrate that ablation of GSH synthesis in mice results not only in reduced expression of lipogenic enzymes but also lower levels of their corresponding lipid species

Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD