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10.1016/j.lfs.2014.05.022 Life Sci

Translation of promising preclinical findings into clinical applications is crucial, as many studies have failed to demonstrate efficacy in clinical trials [123]

Since then, dozens of clinical studies have been published with this ingredient

Regarding citric acid cycle dysfunction, it seems that the formation deficiency of succinyl-CoA, a precursor to succinate, and -ketoglutarate may be involved with the mechanism (Fig