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The authors suggest a potential role of nitric oxide in promoting these findings, as nitric oxide is a signaling molecule known to facilitate vasodilatation by acting on vascular smooth muscle cells [30]

Bachta et al

Norepinephrine and epinephrine are relatively small, highly polar molecules with primary amine groups that are fully protonated at physiological pH and show markedly negative distribution coefficients in aqueous buffer, indicating a strong preference for the aqueous phase 26,27,28,29,30