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Redox disturbances and skeletal muscle fatigue: in vitro and in situ animal studies As discussed throughout this chapter, it is clear that production of ROS increases in contracting skeletal muscle and animal studies provide convincing evidence that ROS contribute to muscle fatigue induced by prolonged muscular contractions (313, 324)

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3.7 Fragile X-associated tremor/ataxia syndrome Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS), typically caused by a premutation in the FMR1 (fragile X messenger ribonucleoprotein 1) gene, is a nervous system disorder in older adults characterized by tremors, ataxia, memory issues, and mood disorders