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For example, based on the analysis of the SANS curves of nucleosomes in various H 2 O/D 2 O solvents, the overall organization of this fundamental subunit of chromatin was described as a spherically averaged structure with most of the histones closely packed into a core of radius 3.2 nm surrounded by a loosely packed DNA-rich shell of 2.0 nm thickness resulting in a particle of 5.2 nm average radius (Hjelm et al., 1977)

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11/12 patients who received intra-articular BPC-157 for knee pain reported significant relief